The Genova GI Effects® Comprehensive Stool Profile

By Genova Diagnostic Laboratories
In Stock
PL-THEDR.COM-GDL03
In stock
Sku#: PL-THEDR.COM-GDL03
In Stock
Fulfilled by TheDR.com - this item will arrive in a separate shipment.

When Should the GI Effects Comprehensive Stool Profile Be Considered?
The GI Effects Comprehensive Stool Profile can reveal important information about the root cause of many common gastrointestinal symptoms such as gas, bloating, indigestion, abdominal pain, diarrhea, and constipation. This stool analysis utilizes biomarkers such as fecal calprotectin to differentiate between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS).

Gut microbes are codependent with one another and with their human host, and the health of one affects the other. A sizable volume of research associates a dysbiotic, or imbalanced gut microbiome with multiple disease states both within and outside of the GI tract. The diverse metabolic activities of the microbiome ultimately impact the human host, and the activities of the human host ultimately affect the health of their microbiome.

The GI Effects Comprehensive Stool Profile Biomarkers
The biomarkers on the GI Effects Comprehensive Profile reflect the 3 key functions of gut health arranged in the “DIG” format: Digestion/Absorption, Inflammation/Immunology, and the Gut Microbiome:

  • Digestion/Absorption:
    • Pancreatic Elastase-1 is a marker of exocrine pancreatic function.
    • Products of Protein Breakdown are markers of undigested protein reaching the colon.
    • Fecal Fat is a marker of fat breakdown and absorption.
  • Inflammation/Immunology:
    • Calprotectin is a marker of neutrophil-driven inflammation. Produced in abundance at sites of inflammation, this biomarker has been proven useful in differentiating between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS).
    • Eosinophil Protein X is a marker of eosinophil-driven inflammation and allergic response.
    • Fecal Secretory IgA is a marker of gut secretory immunity and barrier function.
    • Fecal Occult Blood Test detects hidden blood; fecal immunochemical testing (FIT) has been recommended by the American College of Gastroenterology as the preferred noninvasive test for colorectal cancer screening/detection.
  • Gut Microbiome:
    • Metabolic indicators, including short-chain fatty acids and beta-glucuronidase, demonstrate specific and vital metabolic functions performed by the microbiota.
    • Commensal Bacteria demonstrate the composition and relative abundance of gut organisms.
      • More than 95% of commensal gut organisms are anaerobic and are difficult to recover by traditional (aerobic) culture techniques.
      • GI Effects assesses a set of 24 genera/species that map to 7 major phyla.
    • Bacterial and mycology cultures demonstrate the presence of specific beneficial and pathological organisms.
    • Bacteria and mycology sensitivities are provided for pathogenic or potentially pathogenic organisms that have been cultured. The report includes effective prescriptive and natural agents.
    • Parasitology includes comprehensive testing for all parasites on every parasitology exam ordered.
      • GI Effects provides microscopic fecal specimen examination for ova and parasites (O&P), the gold standard of diagnosis for many parasites.
      • 6 Polymerase chain reaction (PCR) targets detect common protozoan parasites including Blastocystis spp. with reflex subtyping 1-9Cryptosporidium parvum/hominis, Cyclospora cayetanensis, Dientamoeba fragilis, Entamoeba histolytica, and Giardia. PCR for organisms is emerging as a highly sensitive method for infectious organism detection.
      • Selection of a one-day or three-day sample collection is based on the clinician’s clinical index of suspicion for parasitic infection. If there is no/low suspicion, a one-day sample will likely be adequate. For high suspicion, a three-day sample collection is optimal.
  • Additional Biomarkers Available:
    • Campylobacter
    • Clostridium difficile
    • Escherichia coli
    • Fecal Lactoferrin
    • Helicobacter pylori
    • Macro Exam for Worms
    • Zonulin Family Peptide
    • KOH Preparation for Yeast

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  • This test does NOT include a test interpretation consultation. If you are interested in having your test results interpreted please contact our former director of Clinical services Michelle Ross, MS, MA, CNS, LDN, IFMCP at info@michelleross.com once you have received your test results.
  • *Test interpretations must take place within 3 months of placing the test order.
  • Michelle Ross is a Certified Nutrition Specialist, a Licensed Dietitian-Nutritionist and an Institute of Functional Medicine Certified Practitioner. Graduating Summa Cum Laude from the University of Bridgeport, Michelle holds a Master of Science in Human Nutrition and a master’s degree in Education from Pacific Union College. Michelle’s graduate school thesis focused on the complexity of gluten-related disorders and the potentially devastating effects of gluten on the body. She has been extensively trained in the advanced interpretation of functional testing, autoimmune diseases, gluten- and wheat- related disorders, and microbiome health.

Please be sure to read the complete list of terms and conditions for ordering Genova Diagnostic Testing at theDr.com prior to placing your order.