Cyrex Alzheimer’s LINX – Alzheimer’s-Associated Immune Reactivity

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Manufacturer:
Cyrex Laboratories
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Alzheimer’s LINX is a new breakthrough test panel designed to identify key risk factors that the latest medical research has linked to the development of Alzheimer’s disease (AD). It detects immune reactivity to specific environmental antigens and self-tissues, which potentially can contribute to the development of AD, as well as other neurodegenerative conditions. This creates an important window of opportunity for preclinical management of individuals at higher risk of AD, even years before the clinical onset of disease. Alzheimer’s LINX is the result of years of intense research and development, lead by Dr. Aristo Vojdani, a pioneering immunologist, recognized by many as the Father of Functional Immunology. It is a strategically planned panel of biomarkers revealing never-before-seen clinical perspectives of brain-related immune reactivity. 

 

RECOMMENDED FOR CLIENTS WHO:

  • Are interested in preventing the development of Alzheimer’s disease or other neurological disorder. 
  • Are exhibiting early signs of Alzheimer’s disease or other neurological disorder. 
  • Have been diagnosed with Alzheimer’s disease. 
  • Have a history of gastrointestinal disorders and/or diabetes. 
  • Played high-impact sports. 
  • Are immunoreactive against specific pathogens, chemicals and foods

Features in this landmark new panel include:

  • 7 categories of key contributing factors to Cognitive Decline or other neurodegenerative conditions
  • Nearly 40 biomarkers, many of them offered for the first time anywhere
  • Brand New Blood-Brain Barrier antibody biomarkers
  • New biomarker to test immune reactivity to Amyloid-Beta
  • The eight most cross-reactive foods (out of 208 studied) newly-discovered to have potential association with AD
  • New protein biomarkers that reveal immune reactivity and cross reactivity to key brain cells and neurons at the heart of AD
  • New Oral bacterial biomarker shown to be associated with AD
  • Biomarkers for a collection of chemicals and metals discovered to have associations to AD
  • Performed on the Gold Standard ELISA platform, the most reliable lab technology on the market

 

7 groups of KEY contributing factors:

BRAIN PROTEINS • Assessing reactivity to brain proteins beyond amyloid-beta and tau protein

GROWTH FACTORS • Measuring immune reactivity to factors involved in neuronal regeneration

ENTERIC NERVE, ENZYMES AND NEUROLOGICAL PEPTIDES • Assessing immune reactivity to the communication pathway between the gut and the brain

PATHOGENS • Assessing immune reactivity to pathogens known to cross-react with amyloid-beta

CHEMICALS • Biomarkers for a collection of chemicals/heavy metals discovered to have associations to AD

FOODS CROSS-REACTIVE TO AMYLOID BETA • 8 out of 208 common foods, newly discovered to have a potential association with AD.

BLOOD-BRAIN BARRIER AND NEUROFILAMENTS • Blood-Brain Barrier antibody biomarkers • Assess the integrity of the blood-brain barrier 

Antigens Tested (IgG):

Brain Proteins:

  • Tau Protein 
  • Amyloid-Beta Peptide 
  • Rabaptin-5 + Presenilin 
  • Alpha-Synuclein 

 

Growth Factors:

  • Beta Nerve Growth Factor 
  • Brain Derived Neurotrophic Factor 
  • Neurotrophins 
  • Somatotropin

 

Enteric Nerve, Enzymes and Neurological Peptides:

  • Enteric Nerve + Vasoactive Intestinal Peptide
    • Transglutaminases


Pathogens:

  • Oral Pathogens 
  • Enterococcus faecalis 
  • Escherichia coli CDT + Salmonella CDT 
  • Campylobacter jejuni CDT 
  • Herpes Type-1

 

Chemicals:

  • Aluminums 
  • Dinitrophenyl 
  • Ethyl + Methyl Mercury 
  • Phthalates

 

Foods Cross-Reactive To Amyloid Beta:

  • Egg Yolk, raw + cooked 
  • Lentil Lectin + Pea Lectin 
  • Tuna, canned 
  • Hazelnut Vicilin + Cashew Vicilin 
  • Scallops + Squid 
  • Caseins 
  • Alpha-Gliadin + Gliadin Toxic Peptide 
  • Non-Gluten Wheat Proteins

 

Blood-Brain Barrier and Neurofilaments:

  • Blood-Brain Barrier Protein + Claudin-5 
  • Aquaporins 
  • Neurofilament Proteins

 

POSSIBLE INTERFERENCES WITH THE RESULTS OF CYREX TESTS:

While Cyrex is unable to provide an exhaustive list of medications, foods, conditions or other factors that could interfere with the results of a Cyrex test, please note that:

  • Immunosuppressant and corticosteroid drugs can reduce antibody production and cause false-negative results.
  • Recent antigen exposure is necessary in order to measure antibody responses.
  • Infections can interfere with test results.
  • For more information on possible interferences, please consult the FAQs on the Cyrex website.

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Specimen: Serum

 

Important Information about Cyrex Antibody Testing

Your test includes a 30-minute interpretation of your results with Michelle Ross, Director of Clinical Services.

Please Note: The test interpretation consultation must take place within 3 months of placing the test order.

 

*Please read the following prior to placing your lab test order*

  • All sales are final and no refunds will be afforded and you waive any rights to charge-back your purchase with your credit card processor.
  • theDr.com does not participate in, take assignment, or accept any private insurance. We do not provide super bills and cannot assist with claim resolution for laboratory tests or consultations.
  • Orders for this test are accepted form the United States Only. International Orders are not accepted for this test.
  • TheDr.com is unable to ship test kits to the state of New York as per state laws.
  • TheDr.com is unable to ship lab kits to P.O. boxes. Please use a residential or business address.
  • Some lab providers fill out requisition forms ahead of time with client information. To avoid confusion when processing orders, if you are ordering lab kits for multiple people, please place a separate order for each person.
  • After you order a test kit, getting the lab draw and/or completing the test is your responsibility.
  • Test interpretation consultations DO NOT include personalized recommendations. Personalized recommendations are available within our Discovery, Essentials, and Premier programs.
  • The test interpretation consultation that is included in the price of the test must take place within 3 months of placing the test order.
  • Once thedr.com has received your test results, the results will be uploaded to your HIPAA compliant client portal and you will receive an email instructing you how to access them.
  • Cyrex Labs covers a flat rate with contracted labs for the phlebotomy services associated with their test kits requiring a blood draw. Depending on the location and lab, additional draw fees may be required.
  • Once you have purchased your test, your requisition will contain the necessary information to schedule a blood draw here: https://www.cyrexlabs.com/PayformyTest/tabid/126/Default.aspx
  • If you live in a remote location, you may need to travel a distance or ask your local physician or hospital to assist with phlebotomy.
  • We recommend contacting the draw center and scheduling an appointment for your blood draw in advance. 

Please contact testing@thedr.com with questions.

 

Before Placing Your Order Please Read
The Complete Terms and Conditions for Cyrex Test Orders at theDr.com

 

Cyrex Laboratories is CLIA* certified and licensed in the state of Arizona. Cyrex participates in CAP (College of American Pathologists) surveys to assure quality procedures and regulatory compliance. Cyrex Laboratories follows the strictest federal guidelines for the development of its assays.

 

*Congress passed the Clinical Laboratory Improvement Amendments (CLIA) in 1988, establishing quality standards for all laboratory testing to ensure the accuracy, reliability, and timeliness of patient test results regardless of where the test is performed.