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CGP - Array 20: Blood Brain Barrier Permeability

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PL-THEDR.COM-CYREX16-1
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Fulfilled by TheDR.com - this item will arrive in a separate shipment.

Barrier Protein IgG + IgA combined ( CPT CODE : 83516 )

Blood Brain Barrier Protein IgM ( CPT CODE : 83516-59 )

 

CLINICAL SIGNIFICANCE:
When the BBB is inflamed, the tight junctions open and produce a condition called increased BBB permeability or increasingly referred to as “leaky brain” (not the same as leaky brain syndrome). Xenobiotics, viruses, bacterial toxins and other molecules greater than 400 daltons in size, which are normally excluded, can penetrate the BBB. Penetration of the BBB by very large molecules such as LPS or even intact viruses may first cause neuroinflammation, followed by neuroautoimmunity with peripheral or central nervous system (CNS) symptoms.
Disruption of brain barrier results first in the release of BBB proteins and then in
the formation of IgG, IgM or IgA antibodies against tight junctions and BBB proteins. Production of these antibodies against the BBB and other neural cell antigens from a cell-mediated and humoral immune response may indicate a pathological alteration of the protective brain barrier. Continued opening of the BBB and the persistent release of autoantigens for an extended period in adulthood may cause neuronal cell death and an early cognitive decline. Repeated head trauma and traumatic brain injury (TBI) associated with accidents and some sports, such as football or hockey, have also been shown to damage the BBB and the astrocytes.

Important Information about Cyrex Antibody Testing

*Please read the following prior to placing your lab test order*

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  • Orders for this test are accepted form the United States Only. International Orders are not accepted for this test.
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  • Once you have purchased your test, your requisition will contain the necessary information to schedule a blood draw here: https://www.cyrexlabs.com/PayformyTest/tabid/126/Default.aspx
  • If you live in a remote location, you may need to travel a distance or ask your local physician or hospital to assist with phlebotomy.
  • We recommend contacting the draw center and scheduling an appointment for your blood draw in advance. 
  • Please contact testing@thedr.com with questions.

Cyrex Laboratories is CLIA* certified and licensed in the state of Arizona. Cyrex participates in CAP (College of American Pathologists) surveys to assure quality procedures and regulatory compliance. Cyrex Laboratories follows the strictest federal guidelines for the development of its assays.

*Congress passed the Clinical Laboratory Improvement Amendments (CLIA) in 1988, establishing quality standards for all laboratory testing to ensure the accuracy, reliability, and timeliness of patient test results regardless of where the test is performed.