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Array 20 Blood Brain Barrier Permeability

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Blood Brain Barrier Permeability

The BBB naturally permits the passage of essential metabolites, small hydrophobic (lipid soluble) molecules like oxygen, carbon dioxide, hormones, etc. Acting like a filter, the BBB prevents the entry of infectious agents, toxins and other environmental triggers into the nervous system.


Barrier Protein IgG + IgA combined ( CPT CODE : 83516 )

Blood Brain Barrier Protein IgM ( CPT CODE : 83516-59 )


When the BBB is inflamed, the tight junctions open and produce a condition called increased BBB permeability or increasingly referred to as “leaky brain” (not the same as leaky brain syndrome). Xenobiotics, viruses, bacterial toxins and other molecules greater than 400 daltons in size, which are normally excluded, can penetrate the BBB. Penetration of the BBB by very large molecules such as LPS or even intact viruses may first cause neuroinflammation, followed by neuroautoimmunity with peripheral or central nervous system (CNS) symptoms.


Disruption of brain barrier results first in the release of BBB proteins and then in the formation of IgG, IgM or IgA antibodies against tight junctions and BBB proteins. Production of these antibodies against the BBB and other neural cell antigens from a cell-mediated and humoral immune response may indicate a pathological alteration of the protective brain barrier. Continued opening of the BBB and the persistent release of autoantigens for an extended period in adulthood may cause neuronal cell death and an early cognitive decline. Repeated head trauma and traumatic brain injury (TBI) associated with accidents and some sports, such as football or hockey, have also been shown to damage the BBB and the astrocytes.

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  • Michelle Ross is a Certified Nutrition Specialist, a Licensed Dietitian-Nutritionist and an Institute of Functional Medicine Certified Practitioner. Graduating Summa Cum Laude from the University of Bridgeport, Michelle holds a Master of Science in Human Nutrition and a master’s degree in Education from Pacific Union College. Michelle’s graduate school thesis focused on the complexity of gluten-related disorders and the potentially devastating effects of gluten on the body. She has been extensively trained in the advanced interpretation of functional testing, autoimmune diseases, gluten- and wheat- related disorders, and microbiome health.


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*Congress passed the Clinical Laboratory Improvement Amendments (CLIA) in 1988, establishing quality standards for all laboratory testing to ensure the accuracy, reliability, and timeliness of patient test results regardless of where the test is performed.