Array 20 Blood Brain Barrier Permeability

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In Stock
Manufacturer:
Cyrex Laboratories
Fulfilled by TheDR.com - this item will arrive in a separate shipment.

In stock

Before ordering this test, please read: “Important Information about Cyrex Antibody Testing”

The blood brain barrier (BBB) is a physical barrier formed by the arrangement of endothelial cells and tight junctions that line the capillaries which supply blood to the brain. It is a highly selective barrier that restricts the movement of molecules from the blood across to the brain. 

Blood Brain Barrier Permeability

The BBB naturally permits the passage of essential metabolites, small hydrophobic (lipid soluble) molecules like oxygen, carbon dioxide, hormones, etc. Acting like a filter, the BBB prevents the entry of infectious agents, toxins and other environmental triggers into the nervous system.

 

Barrier Protein IgG + IgA combined ( CPT CODE : 83516 )

Blood Brain Barrier Protein IgM ( CPT CODE : 83516-59 )

 

CLINICAL SIGNIFICANCE:
When the BBB is inflamed, the tight junctions open and produce a condition called increased BBB permeability or increasingly referred to as “leaky brain” (not the same as leaky brain syndrome). Xenobiotics, viruses, bacterial toxins and other molecules greater than 400 daltons in size, which are normally excluded, can penetrate the BBB. Penetration of the BBB by very large molecules such as LPS or even intact viruses may first cause neuroinflammation, followed by neuroautoimmunity with peripheral or central nervous system (CNS) symptoms.

 

Disruption of brain barrier results first in the release of BBB proteins and then in the formation of IgG, IgM or IgA antibodies against tight junctions and BBB proteins. Production of these antibodies against the BBB and other neural cell antigens from a cell-mediated and humoral immune response may indicate a pathological alteration of the protective brain barrier. Continued opening of the BBB and the persistent release of autoantigens for an extended period in adulthood may cause neuronal cell death and an early cognitive decline. Repeated head trauma and traumatic brain injury (TBI) associated with accidents and some sports, such as football or hockey, have also been shown to damage the BBB and the astrocytes.
 
 

Important Information about Cyrex Antibody Testing

Your test includes a 30-minute interpretation of your results with Michelle Ross, Director of Clinical Services.

Please Note: The test interpretation consultation must take place within 3 months of placing the test order.

 

*Please read the following prior to placing your lab test order*

  • All sales are final and no refunds will be afforded and you waive any rights to charge-back your purchase with your credit card processor.
  • theDr.com does not participate in, take assignment, or accept any private insurance. We do not provide super bills and cannot assist with claim resolution for laboratory tests or consultations.
  • Orders for this test are accepted form the United States Only. International Orders are not accepted for this test.
  • TheDr.com is unable to ship test kits to the state of New York as per state laws.
  • TheDr.com is unable to ship lab kits to P.O. boxes. Please use a residential or business address.
  • Some lab providers fill out requisition forms ahead of time with client information. To avoid confusion when processing orders, if you are ordering lab kits for multiple people, please place a separate order for each person.
  • After you order a test kit, getting the lab draw and/or completing the test is your responsibility.
  • Test interpretation consultations DO NOT include personalized recommendations. Personalized recommendations are available within our Discovery, Essentials, and Premier programs.
  • The test interpretation consultation that is included in the price of the test must take place within 3 months of placing the test order.
  • Once thedr.com has received your test results, the results will be uploaded to your HIPAA compliant client portal and you will receive an email instructing you how to access them.
  • Cyrex Labs covers a flat rate with contracted labs for the phlebotomy services associated with their test kits requiring a blood draw. Depending on the location and lab, additional draw fees may be required.
  • Once you have purchased your test, your requisition will contain the necessary information to schedule a blood draw here: https://www.cyrexlabs.com/PayformyTest/tabid/126/Default.aspx
  • If you live in a remote location, you may need to travel a distance or ask your local physician or hospital to assist with phlebotomy.
  • We recommend contacting the draw center and scheduling an appointment for your blood draw in advance. 

Please contact testing@thedr.com with questions.

 

Before Placing Your Order Please Read
The Complete Terms and Conditions for Cyrex Test Orders at theDr.com

 

Cyrex Laboratories is CLIA* certified and licensed in the state of Arizona. Cyrex participates in CAP (College of American Pathologists) surveys to assure quality procedures and regulatory compliance. Cyrex Laboratories follows the strictest federal guidelines for the development of its assays.

 

*Congress passed the Clinical Laboratory Improvement Amendments (CLIA) in 1988, establishing quality standards for all laboratory testing to ensure the accuracy, reliability, and timeliness of patient test results regardless of where the test is performed.