Vibrant America IBSSure

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Vibrant Wellness Laboratories
Fulfilled by - this item will arrive in a separate shipment.

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We recommend starting with the Wheat Zoomer test or confirming immunoglobulin status prior to ordering this test. Please read the “Important Information about Antibody Testing (Cyrex and Vibrant America)” section above.


What is Irritable Bowel Syndrome (IBS) and Small Intestinal Bacterial Overgrowth (SIBO)?

IBS is a common disorder that affects the large intestine (colon) and commonly causes cramping, abdominal pain, bloating, gas, diarrhea and constipation. IBS, unlike inflammatory bowel disease, does not cause changes in bowel tissue or increase your risk of colorectal cancer.


IBS is a big issue in the world of gastroenterology. It is the most common GI disorder with worldwide prevalence rates ranging from 10-15%. There are between 2.4 and 3.5 million physician visits annually for IBS in the United States. Recent research has shown that up to 84% of those with IBS test positive for Small Intestinal Bacterial Overgrowth (SIBO).


SIBO is defined as the presence of excessive bacteria in the small intestine. SIBO is frequently implicated as the cause of chronic diarrhea, bloating, nutrient malabsorption, brain fog, anxiety, and intestinal permeability. Patients with SIBO may also suffer from unintentional weight loss or gain, nutritional deficiencies, food intolerances, and osteoporosis.

What is the Mechanism for SIBO Development?

CdtB toxins (cytolethal distending toxin B) are released by gastroenteritis causing bacteria against which antibodies are produced by the immune system. These antibodies interact with a protein called vinculin that is present in the intestinal cell-lining matrix. This interaction compromises the intestinal barrier leading to impaired digestive motility. This is key in SIBO development and recurrence.


Why Vibrant America?

Vibrant IBSSure™ may help to identify patients with IBS-D related SIBO. This blood test can reduce costs, reduce potential false-negatives associated with the current industry standard, the breath test, and assist with monitoring for SIBO recurrence.


How does IBSSure work?

One SST tube (serum tube) is collected and shipped to a CLIA and CAP accredited laboratory. Vibrant’s proprietary array of protein chips capture antibodies to CdtB and Vinculin using a chemiluminescent technology delivering high sensitivity and specificity of detection.


What does a Positive IBSSure mean?

If your result is positive, it is highly likely that you have IBS related SIBO. If IBSSure is inconclusive, you may benefit from the hydrogen/methane breath test. If you are taking steroids, anti-inflammatory medications, biologic agents, or any other immunosuppressive medications, you may not get an accurate reading of your antibody levels.


View Test Brochure Here

View Sample Test Report 


*Your test includes a 15-minute interpretation of your results with Michelle Ross, Director of Clinical Services. Please Note: The test interpretation consultation must take place within 3 months of placing the test order.


Orders accepted from United States only.
Vibrant Wellness tests are not available in New York State.
Vibrant Wellness Laboratories is not contracted with any insurance provider.


*Please read the following prior to placing your lab test order*


            • All sales are final and no refunds will be afforded and you waive any rights to charge-back your purchase with your credit card processor.
            • does not participate in, take assignment, or accept any private insurance. We do not provide super bills and cannot assist with claim resolution for laboratory tests or consultations.
            • Orders for this test are accepted from the United States only. To inquire about international orders, please email:
            • is unable to ship test kits to the state of New York as per state laws.
            • is unable to ship lab kits to P.O. boxes. Please use a residential or business address.
            • Some lab providers fill out requisition forms ahead of time with client information. To avoid confusion when processing orders, if you are ordering lab kits for multiple people, please place a separate order for each person.
            • After you order a test kit, getting the lab draw and/or completing the test is your responsibility.
            • Test interpretation consultations DO NOT include personalized recommendations. Personalized recommendations are available within our Discovery, Essentials, and Premier programs.
            • The test interpretation consultation that is included in the price of the test must take place within 3 months of placing the test order.
            • Once has received your test results, the results will be uploaded to your HIPAA compliant client portal and you will receive an email instructing you how to access them.
            • Vibrant Wellness covers a flat rate with contracted labs for the phlebotomy services associated with their test kits requiring a blood draw. Depending on the location and lab, additional draw fees may be required.
            • To search for a draw center in your area, please click here:
            • If a draw site is not located in your area, a Vibrant Wellness Phlebotomy Services Manager will assist with finding a blood draw center for you. If you live in a remote location, you may need to travel a distance or ask your local physician or hospital to assist with phlebotomy.
            • Please contact with questions.


      Before Placing Your Order Please Read
      The Complete Terms and Conditions for Vibrant Wellness Test Orders at